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Updated: Dec 23, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[New antibiotics for the clinical setting, an overview]
Sylvain Meylan1, Vera Portillo Tunon2, Benoît Guery1
1Service des maladies infectieuses, CHUV, 1011 Lausanne.
New antimicrobial drugs offer hope against rising antibiotic resistance. This review examines recently developed substances and their potential clinical applications to combat this global health threat.
Area of Science:
- Medical research
- Infectious diseases
- Pharmacology
Background:
- Antibiotic resistance is a significant global health challenge.
- The World Health Organisation (WHO) launched a global action plan in 2015 to address this issue.
- Developing new antimicrobial agents is a key strategy.
Purpose of the Study:
- To review novel antimicrobial substances.
- To discuss their applications.
- To evaluate their potential clinical use.
Main Methods:
- Literature review of new antimicrobial agents.
- Analysis of their properties and applications.
- Discussion of clinical relevance.
Main Results:
- Over six new antimicrobial substances have been introduced clinically in the past decade.
- These novel agents represent advancements in combating resistant infections.
- Their specific applications and efficacy are detailed.
Conclusions:
- Novel antimicrobials are crucial for managing antibiotic resistance.
- Continued development and strategic clinical use are essential.
- These new drugs offer promising therapeutic options.
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