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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

296
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
296
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

280
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
280

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Lack of Association Between the Outcomes of Aortic Valve Implantation and Edge-to-Edge Repair at US Transcatheter Valve Programs.

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Hemodynamic Profiling of Patients Undergoing Transcatheter Mitral Edge-to-Edge Repair.

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Nonthrombogenic Roles of the Left Atrial Appendage: JACC Review Topic of the Week.

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Risks of Right Heart Catheterization and Right Ventricular Biopsy: A 12-year, Single-Center Experience.

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The impact of baseline transmitral diastolic mean gradient on left atrial pressure reduction in patients undergoing transcatheter mitral valve edge-to-edge repair.

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Related Experiment Video

Updated: Dec 23, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

445

Transcatheter Aortic Valve Replacement Programs: Clinical Outcomes and Developments.

Vinayak Kumar1, Gurpreet S Sandhu2, Charles M Harper3

  • 1Department of Medicine Mayo Clinic Rochester MN.

Journal of the American Heart Association
|April 18, 2020
PubMed
Summary
This summary is machine-generated.

Transcatheter aortic valve replacement is a revolutionary treatment for severe aortic stenosis. This review covers its history, clinical trials, and technique evolution, offering a clear overview of the evidence.

Keywords:
aortic valve replacementclinical trialcomplicationoutcometranscatheter aortic valve implantation

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Severe aortic stenosis is a critical condition requiring effective treatment.
  • Transcatheter aortic valve replacement (TAVR) has emerged as a significant therapeutic option.
  • Understanding the historical context and evidence base for TAVR is crucial for clinical practice.

Purpose of the Study:

  • To provide a comprehensive historical review of transcatheter aortic valve replacement.
  • To summarize key clinical trials evaluating TAVR efficacy and safety.
  • To describe the technical evolution of the TAVR procedure over time.

Main Methods:

  • Literature review of historical data and seminal publications.
  • Analysis of major randomized controlled trials and observational studies.
  • Synthesis of information on procedural advancements and technique modifications.

Main Results:

  • TAVR has transitioned from an experimental procedure to a standard of care for severe aortic stenosis.
  • Major clinical trials have demonstrated TAVR's non-inferiority and, in some cases, superiority to surgical aortic valve replacement.
  • Significant improvements in TAVR device technology and procedural techniques have enhanced patient outcomes.

Conclusions:

  • Transcatheter aortic valve replacement represents a major advancement in cardiovascular medicine.
  • The robust clinical evidence supports TAVR as a safe and effective treatment for severe aortic stenosis.
  • Continued evolution of TAVR technology promises further improvements in patient care and accessibility.