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Updated: Jul 4, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Nonthrombogenic Roles of the Left Atrial Appendage: JACC Review Topic of the Week
Mohamad Alkhouli1, Luigi Di Biase2, Andrea Natale3
1Department of Cardiology, Mayo Clinic School of Medicine, Rochester, Minnesota, USA.
Abstract:
The atrial appendage (LAA) is a well-established source of cardioembolism in patients with atrial fibrillation. Therefore, research involving the LAA has largely focused on its thrombogenic attribute and the utility of its exclusion in stroke prevention. However, recent studies have highlighted several novel functions of the LAA that may have important therapeutic implications. In this paper, we provide a concise overview of the LAA anatomy and summarize the emerging data on its nonthrombogenic roles.
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