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Updated: Dec 23, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Cost-effectiveness for imaging stable ischemic disease
Silanath Terpenning1, Arthur Stillman1,2
1Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Insights
Optimal medical therapy is the most cost-effective approach for stable ischemic heart disease patients with coronary artery disease. Invasive procedures are reserved for specific cases, with advanced imaging for complex scenarios.
Area of Science:
- Cardiology
- Health Economics
- Medical Imaging
Background:
- Stable ischemic heart disease is a significant cause of illness and death.
- Current diagnostic and management imaging modalities lack a clear cost-effective strategy.
- Evidence-based clinical studies are needed to guide cost-effective approaches.
Purpose of the Study:
- To review recent evidence-based clinical studies and trials.
- To suggest the most cost-effective approach for managing stable ischemic heart disease.
- To discuss the limitations of existing studies.
Main Methods:
- Review of recent evidence-based clinical studies and trials.
- Analysis of multicenter trial results.
- Development of a suggested cost-effective pathway for stable ischemic heart disease management.
Main Results:
- Optimal medical therapy is suggested as the most cost-effective strategy for appropriate coronary artery disease patients.
- Invasive coronary angiography or revascularization is recommended for non-responders or those with >/=50% left main stenosis.
- Stress cardiac magnetic resonance imaging is proposed for patients with non-diagnostic coronary CT angiography due to motion or high coronary calcium, and for optimal medical therapy non-responders.
Conclusions:
- The proposed diagnostic and management pathway appears safe and cost-effective.
- Further modeling is required to confirm the cost-effectiveness of the suggested approach.
- This strategy aims to optimize patient outcomes while managing healthcare costs.
Abstract:
Stable ischemic heart disease remains a major cause of morbidity and mortality. Although there are multiple imaging modalities to diagnose and/or assist in the clinical management, the most cost-effective approach remains unclear. We reviewed the relevant and recent evidence-based clinical studies and trials to suggest the most cost-effective approach to stable ischemic heart disease. The limitations of these studies are discussed. Incorporating the results of recent multicenter trials, we suggest that for appropriate patients with coronary artery disease with any degree of stenosis or presence of coronary calcium, optimal medical therapy may be most cost-effective. Invasive coronary angiography and/or coronary revascularization would be primarily for non-responders or >/=50% left main stenosis. Stress cardiac magnetic imaging would be performed for those patients with non-diagnostic coronary CT angiography from motion and non-responders from optimal medical therapy in non-diagnostic coronary CT angiography group from high coronary calcium. These paths seem to be safe and cost-effective but requires modeling for confirmation.
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