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Updated: Dec 23, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Combating devastating COVID-19 by drug repurposing
1Department of Pharmaceutical Sciences, Mahatma Gandhi Vidyamandir's Pharmacy College, Panchavati, Nashik, 422 003 Maharashtra, India.
Drug repurposing shows promise for treating COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Further clinical trials are needed to validate these potential antiviral therapies.
Area of Science:
- Virology
- Infectious Diseases
- Pharmacology
Background:
- Viral infections, including COVID-19, pose significant global health challenges.
- The lack of specific antiviral drugs for SARS-CoV-2 necessitates exploring alternative treatment strategies.
- Drug repurposing offers a potential avenue for rapid development of COVID-19 therapies.
Discussion:
- This article reviews potential drug candidates for COVID-19 treatment, primarily based on in vitro efficacy.
- Concerns exist regarding adverse effects and the need for robust clinical data for repurposed drugs.
- Off-label use of certain drugs has shown effectiveness in some regions, warranting further investigation.
Key Insights:
- Several repurposed drugs demonstrate efficacy in in vitro studies against SARS-CoV-2.
- Re-evaluation of existing in vitro data is crucial for identifying promising candidates.
- Randomized clinical trials are essential to confirm the safety and effectiveness of these drugs.
Outlook:
- Prioritizing further investigation of these drug candidates is recommended.
- Conducting rigorous randomized clinical trials will provide statistically significant data.
- Successful drug repurposing could expedite the availability of effective COVID-19 treatments.
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