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Updated: Dec 23, 2025

Detecting Migration and Infiltration of Neutrophils in Mice
Published on: February 6, 2020
Contribution of neutrophils in the pathogenesis of rheumatoid arthritis
Lingshu Zhang1, Yi Yuan2, Qiang Xu1
1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR 97239, USA;Rheumatology Section, VA Portland Healthcare System, Portland, OR 97239, USA.
Abstract:
Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.
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