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Cardiovascular disease in HIV patients: recent advances in predicting and managing risk

Padraig McGettrick1, Patrick W G Mallon1,2, Caroline A Sabin3

  • 1Centre for Pathogen Host Research, UCD School of Medicine, University College Dublin , Dublin, Ireland.

Expert Review of Anti-Infective Therapy
|April 21, 2020
PubMed

Insights

Cardiovascular disease (CVD) is a major concern for people with HIV (PLWH). Understanding and managing CVD risk factors, both general and HIV-specific, is crucial for improving health outcomes in this growing population.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in people living with HIV (PLWH).
  • An aging PLWH population presents unique challenges for CVD risk management.
  • CVD risk factors in PLWH may differ from the general population.

Purpose of the Study:

  • To review current data on CVD prevalence, pathogenesis, and contributing factors in PLWH.
  • To examine CVD risk prediction models and influencing factors (general and HIV-specific) in PLWH.
  • To discuss CVD risk management strategies and future therapeutic avenues for PLWH.

Main Methods:

  • Comprehensive literature review of CVD in HIV infection.
  • Analysis of data on CVD prevalence, pathogenesis, and risk factors.
  • Synthesis of information on risk prediction, management, and future therapies.

Main Results:

  • CVD is a significant health challenge for aging PLWH.
  • Multiple, potentially distinct, factors contribute to CVD risk in PLWH.
  • Effective risk prediction and management strategies are essential.

Conclusions:

  • Addressing CVD risk in PLWH requires a multifaceted approach.
  • Further research into HIV-specific CVD pathways is needed.
  • Future management strategies should focus on personalized and preventative care.
Abstract

Keywords:
Anti-retroviral therapy (ART)CVD managementCVD preventionHIVcardiovascular diseaseinflammation

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