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[The morphological characteristics and immunophenotype of renal cell carcinomas with eosinophilic cytoplasm]
Yu I Osmanov1, E A Kogan2, S G Radenska-Lopovok3
1Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; Department of Pathological Anatomy, Research Clinical Center, OAO 'RZhD', Moscow, Russia.
Abstract:
Eosinophilic cellular renal cell carcinomas embrace a wide range of histological types described in the 2016 WHO International Classification of Kidney Tumors. A variety of histological manifestations associated with the features of tumor morphogenesis in this group poses difficulties in differential diagnosis.
Aim:
to investigate the morphological and immunophenotypic features of rare types of renal cell carcinomas with eosinophilic cytoplasm.
Subjects And Methods:
An investigation was conducted using a surgical material from 294 patients with a kidney tumor. An immunohistochemical (IHC) study was performed on paraffin sections according to the standard protocol using a wide panel of antibodies.
Results:
Based on a morphological analysis and IHC study, the tumors were divided into 3 groups: 1) 127 (43%) oncocytic tumors that expressed classical IHC markers for oncocytoma and chromophobe renal cell carcinoma; 2) 50 (17%) oncocytic tumors that did not correspond to the immunophenotypes of oncocytoma and chromophobe renal cell carcinoma; and 3) 117 (40%) eosinophilic cellular nononcocytic renal tumors.
Conclusion:
With the advent of the current differential diagnostic criteria, the classification of renal cell carcinomas continues to expand. To date, a hybrid oncocytic/chromophobic tumor, eosinophilic solid and cystic renal cell carcinoma, and follicular kidney cancer should be regarded as new nosological entities.
