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Related Experiment Video

Updated: Dec 23, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Metabolite Profiling in Anticancer Drug Development: A Systematic Review.

Nadda Muhamad1, Kesara Na-Bangchang1,2,3

  • 1Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

Drug Design, Development and Therapy
|April 21, 2020
PubMed
Summary

Investigating drug metabolites is crucial for cancer chemotherapy development. Understanding metabolite profiles helps identify beneficial or toxic compounds, guiding safer and more effective anticancer drug design.

Keywords:
anticancercancerherbal medicinemetabolismmetabolite profile

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Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Cancer Chemotherapy

Background:

  • Drug metabolism is a key pharmacokinetic process vital in drug development.
  • Investigating metabolite profiles is essential due to potential therapeutic benefits or serious toxicity of metabolites.

Purpose of the Study:

  • To systematically review research on metabolite profiling of conventional and herb-derived anticancer agents.
  • To examine factors influencing metabolite profiling.
  • To determine the relationship between metabolite efficacy and toxicity.

Main Methods:

  • Systematic literature search of PubMed and ScienceDirect databases up to January 2019.
  • Inclusion and exclusion criteria applied to 830 initially identified articles, with 78 selected for analysis.

Main Results:

  • Anticancer agents undergo Phase I (oxidation, hydroxylation, hydrolysis) and Phase II (glucuronidation, methylation, sulfation) metabolism.
  • Species, gender, route, and dose of administration significantly influence metabolite formation.
  • Identified active and toxic metabolites are critical for drug development.

Conclusions:

  • Metabolite profiling is critical for advancing cancer chemotherapy.
  • Understanding metabolic pathways and influencing factors aids in developing safer and more effective anticancer drugs.