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Corneal graft melting: a systematic review
Bin-Bin Zhu1, Jie Zhou1, Jiao Zheng1
1Eye Center, the Affiliated Second Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China.
International Journal of Ophthalmology
|April 21, 2020
Summary
Corneal graft melting after keratoplasty is a serious complication. Understanding its complex causes and risk factors is key to developing targeted therapies and improving patient outcomes.
Area of Science:
- Ophthalmology
- Transplantation Surgery
- Corneal Diseases
Background:
- Corneal graft melting is a severe complication following keratoplasty.
- This condition poses significant challenges in corneal transplantation outcomes.
Purpose of the Study:
- To review the incidence, pathogenesis, risk factors, prognosis, and prevention of corneal graft melting post-keratoplasty.
- To synthesize current knowledge to guide clinical practice.
Main Methods:
- Systematic literature search of PubMed, Web of Science, and WanFang databases.
- Inclusion of clinical reports and animal experiments.
- Independent data extraction and study selection by two reviewers.
Main Results:
- Corneal graft melting is associated with complex pathogenesis.
- Numerous risk factors are identified as closely related to its occurrence.
Conclusions:
- The pathogenesis of corneal graft melting is intricate.
- Identifying and analyzing risk factors are crucial for developing targeted therapies.
- This analysis aids in optimizing clinical management strategies for keratoplasty patients.
