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Updated: Dec 23, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
Suneha Sundaram1, Raj Vuppalanchi1, Romil Saxena2
1Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
Abstract:
Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.
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