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COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities

Bonnie Ky1, Douglas L Mann2

  • 1Department of Medicine, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

JACC. Basic to Translational Science
|April 21, 2020
PubMed

Insights

This review provides cardiovascular and cardio-oncology physicians with essential knowledge on COVID-19 treatments. It explains the rationale behind clinical trials and emerging cardiovascular epidemiology for better patient care.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Oncology

Background:

  • The COVID-19 pandemic spurred numerous clinical trials for SARS-CoV-2.
  • Many treatments under investigation are repurposed drugs for influenza, Ebola, or malaria.
  • These repurposed agents may be unfamiliar to cardiovascular and cardio-oncology specialists.

Purpose of the Study:

  • To equip frontline cardiovascular and cardio-oncology physicians with foundational knowledge on COVID-19 treatments.
  • To enhance understanding of the cardiovascular epidemiology associated with COVID-19.
  • To clarify the biological rationale behind ongoing clinical trials for COVID-19 therapeutics.

Main Methods:

  • Literature review and synthesis of existing data.
  • Analysis of repurposed therapeutic agents for COVID-19.
  • Examination of cardiovascular implications and epidemiological trends.

Main Results:

  • Identification of key repurposed drugs and their mechanisms.
  • Overview of emerging cardiovascular complications in COVID-19 patients.
  • Explanation of the scientific basis for current clinical trials.

Conclusions:

  • Cardiovascular and cardio-oncology physicians need a comprehensive understanding of COVID-19 treatments.
  • Familiarity with repurposed agents and their cardiovascular effects is crucial.
  • This knowledge supports informed clinical decision-making and patient management during the pandemic.
Keywords:
ACE, angiotensin-converting enzymeACE2AT1R, angiotensin II type 1 receptorCI, confidence intervalCOVID-19COVID-19, coronavirus disease-2019CoV, coronavirusFDA, Food and Drug AdministrationIFN, interferonIL, interleukinIQR, interquartile rangeMERS, Middle East respiratory syndromeRAS, renin-angiotensin systemRNA, ribonucleic acidSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2TMPRSS2, transmembrane protease serine 2clinical trialsrenin angiotensin systemsACE2, soluble angiotensin-converting enzyme 2

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