Complementopathies and precision medicine

Area of Science:

• Immunology
• Precision Medicine

Background:

• The complement system, a key part of innate immunity, is increasingly recognized for its role in various diseases.
• Complement-mediated diseases (complementopathies) represent a growing area of clinical research and therapeutic development.

Purpose of the Study:

• To provide a state-of-the-art review of complement biology and its clinical applications.
• To explore novel insights into complement pathways relevant to patient care.
• To discuss the expanding role of complement in diverse medical disciplines and the future of precision medicine.

Main Methods:

• Literature review of current understanding of complement biology.
• Analysis of ongoing and published clinical trials involving complement inhibitors.
• Synthesis of information across hematology, nephrology, obstetrics, transplantation, rheumatology, and neurology.

Main Results:

• Identified numerous complement-mediated diseases with active clinical trials for complement inhibitors.
• Highlighted the expanding scope of complement's involvement in diseases beyond traditional immunology.
• Emphasized the potential for precision medicine approaches in managing complementopathies.

Conclusions:

• Enhanced understanding of complement diagnostics and therapeutics is crucial for clinical practice.
• This review provides a foundation for future research in precision medicine for complement-mediated diseases.
• The field of complementopathies is rapidly evolving, offering new therapeutic avenues.