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Updated: Dec 23, 2025

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

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Complementopathies and precision medicine

Eleni Gavriilaki1, Robert A Brodsky2

  • 1Hematology Department, G. Papanicolaou Hospital, Thessaloniki, Greece.

The Journal of Clinical Investigation
|April 21, 2020
PubMed

Insights

Precision medicine is advancing complement diagnostics and therapeutics for complement-mediated diseases. This review covers complement biology, novel insights, and its role in various diseases, guiding future research.

Area of Science:

  • Immunology
  • Precision Medicine

Background:

  • The complement system, a key part of innate immunity, is increasingly recognized for its role in various diseases.
  • Complement-mediated diseases (complementopathies) represent a growing area of clinical research and therapeutic development.

Purpose of the Study:

  • To provide a state-of-the-art review of complement biology and its clinical applications.
  • To explore novel insights into complement pathways relevant to patient care.
  • To discuss the expanding role of complement in diverse medical disciplines and the future of precision medicine.

Main Methods:

  • Literature review of current understanding of complement biology.
  • Analysis of ongoing and published clinical trials involving complement inhibitors.
  • Synthesis of information across hematology, nephrology, obstetrics, transplantation, rheumatology, and neurology.

Main Results:

  • Identified numerous complement-mediated diseases with active clinical trials for complement inhibitors.
  • Highlighted the expanding scope of complement's involvement in diseases beyond traditional immunology.
  • Emphasized the potential for precision medicine approaches in managing complementopathies.

Conclusions:

  • Enhanced understanding of complement diagnostics and therapeutics is crucial for clinical practice.
  • This review provides a foundation for future research in precision medicine for complement-mediated diseases.
  • The field of complementopathies is rapidly evolving, offering new therapeutic avenues.

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