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Updated: Dec 23, 2025

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Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties

Gregory L Dignon1,2, Robert B Best3, Jeetain Mittal1

  • 1Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, USA;

Annual Review of Physical Chemistry
|April 22, 2020
PubMed
Summary

Biological phase separation forms membraneless organelles through liquid-liquid phase separation (LLPS). This review explores how molecular factors like disorder and modifications influence protein LLPS and multicomponent selectivity.

Keywords:
biomolecular condensatesintrinsically disordered proteinsmulticomponent phase separationphase separation

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