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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

164
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
164
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

139
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
139
Drug Therapy01:28

Drug Therapy

197
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
197
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

164
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
164
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

136
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
136
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

137
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
137

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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Recognizing and Managing Polypharmacy in Advanced Illness.

Shaida Talebreza1, Mary Lynn McPherson2

  • 1Geriatric and Academic Palliative Medicine, Division of Geriatrics, University of Utah School of Medicine, George E. Wahlen Salt Lake City Veterans Affairs Medical Center, 30 North 1900 East SOM AB193, Salt Lake City, UT 84132-0001, USA.

The Medical Clinics of North America
|April 22, 2020
PubMed
Summary
This summary is machine-generated.

Deprescribing medications is crucial for older adults facing polypharmacy risks. Healthcare providers should use compassionate communication to explain this patient-centered approach, ensuring better care for the elderly.

Keywords:
Advanced illnessCommunicationDeprescribingGeriatricsPolypharmacy

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Patient Safety

Background:

  • Older adults are increasingly vulnerable to medication misadventure due to polypharmacy.
  • The burden of multiple medications can outweigh benefits in this population.

Purpose of the Study:

  • To highlight the importance of deprescribing medications in older adults.
  • To emphasize the need for compassionate communication during deprescribing interventions.

Main Methods:

  • Review of current practices in geriatric pharmacotherapy.
  • Analysis of the benefits versus burdens of polypharmacy in the elderly.
  • Guidelines for patient-centered deprescribing communication.

Main Results:

  • Deprescribing medically futile medications can reduce risks for older adults.
  • Compassionate communication is key to successful deprescribing interventions.
  • Focusing on patient-centric benefits improves acceptance of deprescribing.

Conclusions:

  • Deprescribing is a vital intervention for optimizing medication regimens in older adults.
  • Effective and empathetic communication strategies are essential for successful deprescribing.
  • This approach prioritizes patient well-being and reduces medication-related harm.