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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.3K

Arboviruses related with chronic musculoskeletal symptoms

Claudia Diniz Lopes Marques1, Aline Ranzolin1, Nara Gualberto Cavalcanti1

  • 1Rheumatology Department, Hospital das Clínicas, Universidade Federal de Pernambuco, Brazil.

Best Practice & Research. Clinical Rheumatology
|April 22, 2020
PubMed

Insights

Arboviruses, like chikungunya virus (CHIK), cause widespread epidemics and chronic musculoskeletal issues. This review details alphavirus diseases, focusing on CHIK

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Arboviruses are transmitted by arthropods, with alphaviruses causing significant human diseases.
  • Chikungunya virus (CHIK) is a notable alphavirus causing epidemics with chronic health impacts.
  • Alphavirus infections frequently lead to persistent musculoskeletal symptoms.

Purpose of the Study:

  • To review the pathophysiology, clinical features, diagnosis, and treatment of alphaviruses.
  • To specifically focus on chikungunya fever (CHIK) and its chronic musculoskeletal manifestations.
  • To provide a comprehensive overview for understanding and managing alphavirus infections.

Main Methods:

  • Literature review of arboviruses and alphaviruses.
  • Focus on studies detailing chikungunya virus (CHIK) and related alphavirus infections.
  • Synthesis of information on disease mechanisms, clinical presentation, diagnostic methods, and therapeutic strategies.

Main Results:

  • Alphaviruses, particularly CHIK, are associated with severe epidemics and long-term health problems.
  • Chronic musculoskeletal symptoms are a hallmark of many alphavirus infections.
  • CHIK is the most extensively studied alphavirus, providing significant insights into disease progression.

Conclusions:

  • Alphavirus infections, especially CHIK, pose a significant global health challenge due to their epidemic potential and chronic sequelae.
  • Understanding the physiopathology and clinical spectrum of alphaviruses is crucial for effective management.
  • Further research and clinical attention are needed for chronic musculoskeletal symptoms associated with alphavirus infections.
Keywords:
AlphavirusesArbovirusesChikungunya feverChikungunya virusChronic pain

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