Detection of ¹⁸F-FDG Dose Leakage Using a Topical Device

Area of Science:

• Nuclear medicine
• Radiopharmacy
• Medical imaging

Background:

• Positron Emission Tomography (PET) relies on accurate pharmacokinetic modeling for quantitative analysis, such as Standardized Uptake Value (SUV) calculations.
• Predictable intravenous radiotracer dose delivery is crucial for reliable PET imaging and SUV accuracy.
• Partial extravasation of the administered dose can compromise dose delivery predictability and potentially lead to inaccurate SUV calculations.

Observation:

• A case mimicking extravasation during routine ¹⁸F-FDG PET administration was identified.
• The event was determined to be dose leakage during infusion via an automatic injector, not partial extravasation.
• The Lara device, utilizing topical sensors, was employed for monitoring.

Findings:

• The Lara device offers a simple, noninvasive method to detect partial dose extravasation.
• In this case, the Lara device aided in the timely identification and critical evaluation of dose leakage during automatic injector infusion.
• The device proved useful for rapid problem-solving in a clinical setting.

Implications:

• Noninvasive monitoring of radiotracer delivery using devices like the Lara system can enhance the reliability of PET imaging.
• Early detection of dose delivery issues, whether extravasation or leakage, allows for prompt corrective actions.
• Improved dose delivery accuracy benefits patient outcomes and the overall efficiency of PET practices.