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Updated: Dec 23, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
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Publisher Correction: Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction

Peter Ulz1, Samantha Perakis1, Qing Zhou1

  • 1Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.

Nature Communications
|April 22, 2020
PubMed

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Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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