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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Impedimetric Aptamer-Based Biosensors: Applications.

John-Alexander Preuß¹, Peggy Reich², Nicole Bahner³

¹Institute of Technical Chemistry, Leibniz Universität Hannover, Hannover, Germany.

Advances in Biochemical Engineering/Biotechnology

|April 22, 2020

Summary

This summary is machine-generated.

Recent advances in impedimetric aptamer-based biosensors offer potential for handheld medical and environmental testing. This review covers their performance and applications in biotechnology, summarizing benefits and challenges.

Keywords:

Aptamer Aptasensor Bacteria Biomarker Biosensor Cancer Contaminants Diagnostics Disease Drug Environmental Food industry Health care Impedance Infection Monitoring Pathogen Point-of-care Serum Therapy Toxins Tumor marker Virus

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Area of Science:

Biotechnology
Biosensor Technology
Analytical Chemistry

Background:

Aptamer-based biosensors are promising for point-of-care diagnostics.
Impedimetric detection offers a label-free approach.
Recent developments have expanded their applications in various fields.

Purpose of the Study:

To review recent advances in aptamer-based impedimetric biosensors for biotechnology applications.
To detail biosensors developed for medical, environmental, and food control analytes.
To summarize the performance, benefits, and challenges of these biosensors.

Main Methods:

Literature review of recent advances in aptamer-based impedimetric biosensors.
Analysis of biosensor performance metrics: sensitivity, selectivity, response time.
Evaluation of real sample validation and identified challenges.

Main Results:

Numerous aptamer-based impedimetric biosensors have been developed for diverse analytes.
Performance metrics like sensitivity and selectivity vary across different designs.
Real sample validation is crucial for practical application, with ongoing challenges.

Conclusions:

Impedimetric aptasensors show significant potential for handheld and point-of-care applications.
Further research is needed to overcome challenges in selectivity and real-world validation.
These biosensors are valuable tools for medical, environmental, and food biotechnology.