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Related Concept Videos

Chromatin Packaging01:32

Chromatin Packaging

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Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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Increasing Complexity in Wireframe DNA Nanostructures.

Petteri Piskunen1, Sami Nummelin1, Boxuan Shen1

  • 1Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, Finland.

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|April 23, 2020
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Summary
This summary is machine-generated.

Wireframe DNA nanostructures offer an advancement over traditional DNA origami, enabling complex, hollow structures. Automated design processes are paving the way for a new era in DNA nanotechnology.

Keywords:
DNA nanotechnologyDNA origamialgorithmic designbiomaterialscomputer-aided designmeshingnanofabricationself-assemblytop-downwireframe structures

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Area of Science:

  • Structural DNA nanotechnology
  • Biotechnology
  • Nanomaterials

Background:

  • DNA origami is a common method for creating custom DNA shapes using packed DNA helices.
  • Existing DNA origami techniques have limitations, including restricted lattice types, manual scaffold routing, and difficulty fabricating hollow structures.
  • Hollow DNA nanostructures may offer advantages for biological applications like drug delivery.

Purpose of the Study:

  • To review recent advancements in wireframe DNA nanostructures.
  • To discuss methods for overcoming limitations of traditional DNA origami.
  • To explore the potential applications of wireframe DNA nanostructures.

Main Methods:

  • Review of wireframe DNA nanostructure design methods.
  • Discussion of meshing and rendering techniques for DNA structures.
  • Analysis of automated design processes for DNA nanostructures.

Main Results:

  • Wireframe DNA nanostructures overcome limitations of DNA origami, allowing for more complex and hollow designs.
  • Recent advancements enable automated design processes for wireframe DNA structures.
  • The evolution of these methods expands the accessible shape space for DNA nanotechnology.

Conclusions:

  • Wireframe DNA nanostructures represent a significant progress in DNA nanotechnology.
  • Automated design and cost-effective production will accelerate the development and application of DNA nanostructures.
  • This field is poised for a new era with increasing potential applications in areas like drug delivery.