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Weight gain in infants with Pierre Robin sequence

Josip Tomic1, Philipp Metzler1, Andre Alcon2

  • 1Department of Oral and Maxillofacial Surgery, Medical University of Graz, Graz, Austria.

Journal of Cranio-Maxillo-Facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
|April 23, 2020
PubMed

Insights

Infants with Pierre Robin Sequence (PRS) experienced significant weight gain using a modified palatal plate (MPP). This treatment also reduced the need for early airway surgery in these infants.

Area of Science:

  • Craniofacial anomalies
  • Pediatric surgery
  • Neonatal care

Background:

  • Pierre Robin Sequence (PRS) is characterized by micrognathia, glossoptosis, and airway obstruction.
  • Failure to thrive (FTT) is a common complication in infants with PRS.
  • Current management often involves surgical interventions to address airway issues.

Purpose of the Study:

  • To evaluate the efficacy of the modified palatal plate (MPP) in promoting weight gain in infants with PRS.
  • To assess the impact of MPP treatment on the need for surgical airway management.

Main Methods:

  • Retrospective study of 14 infants with isolated and syndromic PRS treated with MPP.
  • Primary outcome: infant weight gain over three months post-birth.
  • Data collected: demographics, comorbidities, genetic testing, and surgical interventions.

Main Results:

  • 86% of infants showed statistically significant weight gain (p < 0.001) within three months.
  • Mean weight increased from 3147g to 4435g.
  • No infants required mandibular distraction or tongue-lip adhesion for airway management; 21% needed tracheotomy.

Conclusions:

  • MPP treatment leads to significant weight gain in PRS infants.
  • MPP may reduce the need for early surgical airway interventions.
  • Accelerated weight gain may influence timing of future surgical procedures.
Abstract

Keywords:
Modified palatal platePierre Robin sequenceWeight gain

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