Cancer Chemoprevention Using Nanotechnology-Based Approaches.

Area of Science:

• Oncology
• Nanotechnology
• Preventive Medicine

Background:

• Cancer incidence remains high, affecting nearly 40% of individuals, leading to significant mortality and socioeconomic burden.
• Current treatments face challenges, necessitating novel approaches like chemoprevention to reduce cancer occurrence and recurrence.
• Nanotechnology presents a promising avenue for enhancing chemoprevention efficacy and safety.

Purpose of the Study:

• To review recent advancements in nanotechnology-based chemoprevention strategies for various cancers.
• To emphasize the application of these strategies in lung, colorectal, pancreatic, and breast cancers.
• To identify unmet needs and challenges for clinical translation of nanochemoprevention.

Main Methods:

• Literature review of recent studies on nanotechnology applications in cancer chemoprevention.
• Focus on studies detailing specific nanotechnology-based agents and their mechanisms.
• Analysis of clinical translation potential and identified research gaps.

Main Results:

• Nanotechnology enhances drug delivery, improves bioavailability, and enables targeted action of chemopreventive agents.
• Demonstrated efficacy of nanochemoprevention in preclinical models for lung, colorectal, pancreatic, and breast cancers.
• Various nanomaterials, including nanoparticles, liposomes, and dendrimers, show significant potential.

Conclusions:

• Nanotechnology-based chemoprevention holds significant promise for reducing cancer incidence and improving patient outcomes.
• Further research and development are crucial to overcome challenges in clinical translation and achieve widespread application.
• Targeted nanodelivery systems offer a safer and more effective approach to cancer prevention.