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Related Experiment Video

Updated: Dec 23, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Irisin ameliorates bone loss in ovariectomized mice.

Y Luo1,2,3,4, Y Ma1,2,3,4, X Qiao1,2,3,4

  • 1Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China.

Climacteric : the Journal of the International Menopause Society
|April 23, 2020
PubMed
Summary

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Irisin treatment prevented bone loss in ovariectomized (OVX) mice by improving bone microarchitecture. This study suggests irisin as a potential therapy for postmenopausal osteoporosis.

Area of Science:

  • Bone biology
  • Endocrinology
  • Osteoporosis research

Background:

  • Postmenopausal osteoporosis is a significant health concern.
  • Ovariectomy (OVX) in mice is a common model for studying postmenopausal osteoporosis.
  • Understanding novel therapeutic targets is crucial for bone health.

Purpose of the Study:

  • To investigate the effects of irisin on bone structure and strength in OVX mice.
  • To explore irisin as a potential treatment for postmenopausal osteoporosis.

Main Methods:

  • Ovariectomized mice received intraperitoneal injections of recombinant irisin (r-irisin) or saline twice weekly for 5 weeks.
  • Evaluated femur trabecular bone structure, tibia bone strength, and serum biochemical markers.
Keywords:
Postmenopausal osteoporosisbone parametersexercise-induced irisinovariectomized

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Main Results:

  • r-irisin treatment preserved trabecular bone structure in OVX mice.
  • Significant improvements in bone mineral density, bone volume/tissue volume, connection density, and trabecular number were observed.
  • Increased bone stiffness, osteoblast numbers, and osteocalcin levels, with decreased osteoclast numbers and tartrate-resistant acid phosphatase.

Conclusions:

  • Irisin enhances osteoblast activity and suppresses osteoclast formation, maintaining bone mass and quality in OVX mice.
  • Irisin preserves bone microarchitecture by establishing a new metabolic balance.
  • This research highlights irisin's therapeutic potential for postmenopausal osteoporosis.