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Updated: Dec 23, 2025

Preparation of Functional Silica Using a Bioinspired Method
Published on: August 1, 2018
Biomineralized nanosilica-based organelles endow living yeast cells with non-inherent biological functions
Yi Chang1, Tingting Liu1, Peng Liu2
1Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. sunshinyma@hotmail.com.
Abstract:
We propose a biomimetic strategy to construct engineered yeast cells (EYCs) by building intracellular silica nanoscaffolds as biomimetic organelles. These nanosilica-based organelles can coordinate with loaded drug and yeast as a shell could prevent drug leakage. In vivo results show that EYCs serve as a dually responsive drug delivery system, targeted with extracellular caps (folate) and triggered by intracellular SiO2 at the low pH of cancer tissue.
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