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A statistical assessment of clinical equivalence
1Institute of Medical Biometry, University of Tubingen, F.R.G.
Statistics in Medicine
|December 1, 1988
Abstract:
An observed confidence distribution is proposed as a measure of strength of evidence for practically equivalent efficacies of two treatments. The concept is independent of prior opinions about relevant sizes of a difference in efficacy. It also avoids retrospective power calculations for trials with missed recruitment goals and allows combination of the confidence from independent experiments.