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Bench to bedside defining calcific aortic valve disease: osteocardiology
Nalini M Rajamannan1,2, Luis M Moura3, Patricia Best4
1Division of Biochemistry and Molecular Biology, Visiting Scientist Mayo Clinic , Rochester, MN, USA.
Expert Review of Cardiovascular Therapy
|April 23, 2020
Summary
Calcific aortic valve disease (CAVD) is an active process, not degenerative. Osteocardiology research explores cellular mechanisms and imaging for timely therapeutic intervention in CAVD.
Area of Science:
- Cardiovascular Research
- Osteocardiology
- Valvular Heart Disease
Background:
- Calcific aortic valve disease (CAVD) was previously considered degenerative but is now understood as an active cellular process.
- Understanding the cellular mechanisms driving calcific phenotypes is crucial for disease management.
- Multimodality imaging is key for assessing calcification progression and guiding therapy timing.
Purpose of the Study:
- To review the emerging field of osteocardiology.
- To define the cellular mechanisms of osteogenic phenotype development in the heart and vasculature.
- To discuss the application of multimodality imaging in CAVD.
Main Methods:
- Literature review focusing on osteocardiology and CAVD.
- Discussion of cellular mechanisms in osteogenic phenotype development.
- Analysis of multimodality imaging criteria for early disease detection.
Main Results:
- The review highlights osteocardiology as a key field for understanding CAVD.
- It emphasizes the active, cellular nature of the disease process.
- Appropriate use criteria for imaging in CAVD are discussed.
Conclusions:
- The authors integrate basic science and clinical perspectives.
- The review supports the osteocardiology theory for CAVD development.
- It underscores the importance of imaging for therapeutic timing.
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