[Toward a preventive management Alzheimer's disease].
B Dubois1,2,3,4,5, S Bombois1,4, N Villain1,3
1Service des maladies cognitives et comportementales, Institut de la mémoire et de la maladie d'Alzheimer (IM2A), hôpital de la Salpêtrière, AP-PH, 47, boulevard de l'Hôpital, 75013 Paris, France.
Bulletin De L'Academie Nationale De Medecine
|April 24, 2020
Summary
Alzheimer's disease (AD) management requires earlier intervention. Lifestyle changes and new amyloid-targeting therapies offer hope for preventing or delaying cognitive decline and dementia.
Area of Science:
- Neurology
- Public Health
- Gerontology
Context:
- Alzheimer's disease (AD) and other dementias pose a growing public health challenge.
- Emerging data suggest lifestyle interventions can impact future cognitive decline in young adults and delay disease onset in at-risk elderly.
- A novel monoclonal antibody targeting amyloid plaques shows significant efficacy in early-stage AD.
Purpose:
- To re-evaluate current strategies for managing cognitive disorders, particularly AD.
- To advocate for earlier, preventive interventions, even before symptom onset.
- To outline a new care model integrating predictive algorithms and specialized prevention clinics.
Summary:
- Predictive algorithms using demographic, genetic, and clinical data can identify at-risk individuals.
- Expert centers will function as 'dementia prevention clinics' to test interventions and provide education.
- These clinics will offer risk disclosure, therapeutic education, and early pharmacological treatments for pre-symptomatic AD.
Impact:
- This proactive approach aims to significantly alter the course of AD and other dementias.
- It facilitates the timely application of emerging pharmacological treatments.
- The strategy shifts focus from late-stage management to early intervention and prevention.
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