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The tripeptide GHG as an unexpected hydrogelator triggered by imidazole deprotonation
Morgan Hesser1, Lavenia Thursch, Todd Lewis
1Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA. rschweitzer-stenner@drexel.edu.
Soft Matter
|April 24, 2020
Abstract:
The tripeptide glycyl-histidyl-glycine (GHG) self-assembles into long, crystalline fibrils forming a strong hydrogel (G'∼ 50 kPa) above a critical concentration of 40 mM upon the deprotonation of its imidazole group. Spectroscopic data reveal a mixture of helically twisted β-sheets and monomers to coexist in the gel phase.

