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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
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Synthesizing Chiral Drug Intermediates by Biocatalysis
Wei Jiang1, Baishan Fang2,3,4
1Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian, China. wjiang@hqu.edu.cn.
Applied Biochemistry and Biotechnology
|April 24, 2020
Summary
Chiral drugs are crucial for efficacy and safety. Biocatalysis offers a green chemistry approach for synthesizing these complex chiral drug intermediates with high selectivity.
Area of Science:
- Medicinal Chemistry
- Biotechnology
- Green Chemistry
Background:
- Chirality is essential for drug efficacy and safety, with 57% of marketed drugs being chiral.
- Chiral compounds constitute 99% of purified natural products, highlighting their biological significance.
- Biocatalysis presents a powerful strategy for selective chemical transformations.
Purpose of the Study:
- To review biocatalytic systems for synthesizing chiral drug intermediates.
- To discuss the application potential of these systems in the pharmaceutical industry.
- To emphasize the role of biocatalysis in green chemistry for drug production.
Main Methods:
- Review of literature on microbial and enzymatic biocatalysis.
- Analysis of successful biocatalytic syntheses of key chiral drug intermediates.
- Discussion of enantio-, chemo-, and regio-selectivities achieved through biocatalysis.
Main Results:
- Biocatalysis enables the synthesis of intermediates for numerous important drugs, including sitagliptin, pregabalin, and atorvastatin.
- Functional microorganisms and their derived biocatalysts demonstrate high selectivity in bioconversions.
- Established biocatalytic routes offer efficient and selective pathways for chiral synthesis.
Conclusions:
- Biocatalysis is a vital tool in medicinal chemistry for producing chiral drugs.
- Further development of biocatalysis is expected to enhance pharmaceutical production.
- Increased utilization of biocatalysis aligns with green chemistry principles for sustainable drug manufacturing.
Keywords:
Anti-Alzheimer’s drugsBiocatalysisChiral drug intermediateMetabolic engineeringSynthetic biologyMore Related Videos
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