Flavonoid-Based Cancer Therapy: An Updated Review

Area of Science:

• Phytochemistry
• Oncology
• Molecular Biology

Background:

• Cancer remains a leading cause of global mortality, driving research for novel therapeutic strategies.
• Phytochemicals, particularly flavonoids, have emerged as promising agents in cancer treatment.
• Flavonoids are diverse polyphenols found in plants, fruits, vegetables, and teas.

Purpose of the Study:

• To review the relationship between flavonoid consumption and cancer risk.
• To discuss the anticancer effects of flavonoids on human cancer cells.
• To explore the mechanisms of action of effective flavonoids in various cancers.

Main Methods:

• Literature review of recent in vivo and in vitro studies.
• Analysis of flavonoid subclasses including flavonols, anthocyanins, flavanones, flavones, isoflavones, and chalcones.
• Evaluation of molecular targets and signaling pathways modulated by flavonoids.

Main Results:

• Flavonoids exhibit anticancer properties through antioxidant and anti-inflammatory activities.
• They modulate key cellular processes like survival, proliferation, angiogenesis, and metastasis.
• Specific flavonoids demonstrate efficacy across various human cancer cell types.

Conclusions:

• Flavonoids represent a hopeful therapeutic avenue for cancer treatment.
• Their consumption may influence cancer risk and progression.
• Further research into specific flavonoids and their mechanisms is warranted for clinical application.