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STAT signaling in polycystic kidney disease

Sebastian Strubl1, Jacob A Torres2, Alison K Spindt2

  • 1Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106-9625, USA; Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Cellular Signalling
|April 24, 2020
PubMed
Summary

Polycystic kidney disease (PKD) involves mutations in the PKD1 gene affecting polycystin1 (PC1). This review explores how PC1 regulates signal transducer and activator of transcription (STAT) pathways, which are often dysregulated in PKD.

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