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Updated: Dec 23, 2025

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages
S S Bochkareva1, A V Karaulov1,2, A V Aleshkin3
1G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
Abstract:
Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation.
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