Patient perspectives on variant reclassification after cancer susceptibility testing
Colin M E Halverson1,2, Laurie M Connors3, Bronson C Wessinger4
1Center for Bioethics, Indiana University School of Medicine, Indianapolis, IN, USA.
Molecular Genetics & Genomic Medicine
|April 25, 2020
Summary
Reclassified genetic test results rarely caused distress or decreased trust, but patients had trouble remembering the updated information. Improving communication about genetic testing changes is crucial for patient understanding.
Area of Science:
- Genetics
- Medical uncertainty
- Patient perception
Background:
- Impact of reclassification on patient trust in genetics-based care is unknown.
- Genetic test results can change, affecting patient management.
- Understanding patient perception of reclassified genetic tests is important.
Purpose of the Study:
- To investigate patient perceptions of reclassified genetic test results.
- To assess the impact on medical uncertainty and trust in genetic care.
- To evaluate patient recall of updated genetic test interpretations.
Main Methods:
- Conducted semistructured telephone interviews with 20 patients.
- Included patients with reclassified hereditary cancer genetic test results.
- Focused on patients tested within the last six years.
Main Results:
- Most patients did not report distress from reclassification.
- A minority of patients showed decreased trust in medical genetics.
- Recall of new genetic test interpretations was limited despite re-engagement.
Conclusions:
- Reclassification of genetic tests is a significant healthcare issue.
- Patients generally maintained trust despite result changes.
- Low comprehension and retention of updated genetic information highlight communication gaps.
- Further research is needed to enhance patient communication regarding reclassified results.
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