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Prevention of Asthma: Targets for Intervention
Michelle C Maciag1, Wanda Phipatanakul1
1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Chest
|April 25, 2020
Summary
Asthma prevention strategies have shown limited success due to the condition's complexity. Personalized approaches targeting genetic and environmental factors show promise for future asthma prevention.
Area of Science:
- Pulmonology and Allergy
- Environmental Health
Background:
- Asthma affects over 300 million globally, with numbers rising rapidly.
- Current prevention strategies targeting atopy, microbiome, viral infections, and pollutant exposure have yielded limited success.
- Asthma's heterogeneity, influenced by genetic and environmental factors, complicates prevention efforts.
Purpose of the Study:
- To review existing asthma prevention interventions.
- To identify ongoing clinical trials in asthma prevention.
Main Methods:
- Review of published literature on asthma prevention strategies.
- Identification and summary of active clinical trials in asthma prevention.
Main Results:
- Many interventions studied have had limited success in preventing asthma.
- Ongoing clinical trials are exploring various prevention avenues.
Conclusions:
- Asthma prevention requires a personalized approach considering individual genetic variations and phenotypes.
- Future research should focus on tailoring strategies based on biomarkers and distinct asthma profiles.
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