Related Experiment Video

Updated: Dec 23, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.9K

A Dutch consensus statement on the diagnosis and treatment of ANCA-associated vasculitis

E Dirikgil1, S W Tas, A Rutgers

  • 1Leiden University Medical Center, Leiden, the Netherlands.

The Netherlands Journal of Medicine
|April 26, 2020
PubMed

Insights

Dutch experts reached national consensus on diagnosing and treating antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This initiative aims to improve clinical decision-making and guideline implementation for AAV patients in daily practice.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Clinical Practice Guidelines

Background:

  • Guidelines exist for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) diagnosis and treatment.
  • Clinical practice requires implementation strategies for guideline adherence.
  • A Dutch initiative aimed to establish national consensus for AAV care.

Purpose of the Study:

  • To develop a national, multidisciplinary consensus on AAV diagnosis and treatment.
  • To create an actionable strategy for implementing guideline-derived recommendations.
  • To support clinical decision-making in daily AAV patient care.

Main Methods:

  • A multidisciplinary working group addressed AAV diagnosis, terminology, and treatment.
  • National consensus was achieved using a Delphi-based method and online survey.
  • Consensus required 70% agreement on statements regarding AAV care.

Main Results:

  • Ninety-eight professionals participated in assessing 50 statements on AAV diagnosis and treatment.
  • Consensus was reached on 37 out of 50 statements (74%).
  • Agreement was achieved on a diagnostic strategy and a treatment algorithm for AAV patients.

Conclusions:

  • A national, multidisciplinary consensus on AAV diagnosis and treatment strategy was established in the Netherlands.
  • This consensus facilitates the implementation of guideline recommendations into clinical practice.
  • Future research will evaluate AAV care implementation and practice variation.
Abstract

More Related Videos

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

36.9K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.5K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
343
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
367
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
257
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
263
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
218
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
147