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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Barrett Esophagus-I: Introduction01:21

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
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Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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Dabigatran-induced esophagitis: A case report.

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Summary
This summary is machine-generated.

Dabigatran can cause esophagitis, a condition often overlooked. This case shows successful treatment with H. pylori eradication and proton pump inhibitors, even while continuing dabigatran.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Dabigatran, an anticoagulant, is used for atrial fibrillation, deep vein thrombosis, and pulmonary embolism.
  • Gastrointestinal mucosal injury, including esophagitis, is a potential adverse effect of dabigatran.
  • This risk is frequently underestimated in clinical practice.

Observation:

  • A 77-year-old woman presented with retrosternal pain, dysphagia, and upper abdominal discomfort.
  • Esophagogastroduodenoscopy revealed longitudinal sloughing mucosal casts in the distal esophagus.
  • Histology showed squamous epithelium with neutrophil infiltration, degeneration, and Helicobacter pylori.

Findings:

  • The patient was diagnosed with dabigatran-induced esophagitis.
  • Symptoms resolved within two weeks after H. pylori eradication therapy and proton pump inhibitor treatment.
  • Dabigatran therapy was continued throughout the treatment period.

Implications:

  • Physicians should be aware of the clinical and endoscopic features of dabigatran-induced esophagitis.
  • H. pylori testing and eradication are crucial for patients on long-term dabigatran therapy.
  • This approach allows for continued anticoagulation while managing esophagitis.