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Published on: February 3, 2023
Evaluation of using spray-dried glutinous rice starch as a direct compression hydrophilic matrix tablet
Jomjai Peerapattana1, Pornpun Laovachirasuwan2, Patteera Sodata3
1Center of Research and Development for Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Background:
Our previous study found that spray-dried glutinous rice starch (sGRS) is larger in size, rounder in shape and better in flowability than native GRS. It has the potential to be used for direct compression hydrophilic matrix (HM) tablets.
Objective:
This study aimed to investigate the factors that affect the propranolol release from directly compressed sGRS HM tablets.
Methods:
The effects of the amount of sGRS, the compaction pressure and the amount of magnesium stearate on the drug release rate from sGRS directly compressed HM were investigated. In vitro drug releases were performed. The dilution potential of sGRS was investigated.
Results:
The higher the sGRS content, the slower the release rate of propranolol. The compaction pressure and the amount of magnesium stearate did not significantly affect the release rate of the drug. The sGRS showed plastic deformation under compaction with a dilution potential of 46%.
Conclusions:
sGRS can be used as a direct compression HM. The amount of sGRS significantly affected the release rate of the drug from the matrix.
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