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Monocyte CD36 expression associates with atherosclerotic burden in diabetes mellitus

Jayanthi Chandran1, Neelam Wadhwa2, S V Madhu3

  • 1Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, University of Delhi, Delhi 110095, India; Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India(1).

Diabetes Research and Clinical Practice
|April 26, 2020
PubMed

Insights

Monocyte CD36 (mCD36) shows higher levels in type 2 diabetes patients, especially those with coronary artery disease. This biomarker effectively detects atherosclerosis and stratifies risk, even in individuals with normal ankle-brachial index.

Area of Science:

  • Cardiovascular Research
  • Diabetes Mellitus Research
  • Biomarker Discovery

Background:

  • Monocyte CD36 (mCD36) is implicated in oxidized low-density lipoprotein uptake and foam cell formation.
  • mCD36 is explored as a potential non-invasive biomarker for atherosclerosis (ATH) in type 2 diabetes mellitus (DM).

Purpose of the Study:

  • To evaluate the expression of mCD36 in patients with type 2 diabetes.
  • To assess the correlation of mCD36 expression with atherosclerosis indicators like the ankle-brachial index (ABI) and coronary artery disease (CAD).

Main Methods:

  • Flow cytometry was used to measure mCD36 expression.
  • Participants included 70 type 2 DM patients (40 with CAD, 30 without) and 30 normoglycemic controls (NGCs).
  • mCD36 levels were compared against ABI values and glycosylated hemoglobin (HbA1c).

Main Results:

  • Type 2 DM patients exhibited significantly higher mCD36 levels than NGCs.
  • Elevated mCD36 was observed in DM patients with CAD and poor glycemic control (HbA1c ≥ 7%).
  • All 30 subjects with compromised ABI (≤0.9) had CAD and higher mCD36 indices; mCD36 levels increased progressively from NGCs to diabetics with and without CAD.

Conclusions:

  • mCD36 plays a significant role in atherogenesis.
  • mCD36 serves as a robust marker for ATH, correlating well with ABI.
  • mCD36 can stratify ATH risk in individuals even with a normal ABI.
Abstract

Keywords:
Ankle brachial indexAtherosclerosisCD36Diabetes mellitusFlowcytometry

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