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Alcoholism and Osteoimmunology.

Xiuwen Wang¹, Xiang Chen¹, Lingyun Lu¹

¹Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

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|April 27, 2020

Summary

Chronic alcohol consumption harms bone health, leading to conditions like osteoporosis. Understanding the role of osteoimmunology in alcoholic bone disease is crucial for developing new treatments.

Keywords:

Alcohol bone remodeling inflammatory factor osteoimmunology osteopenia oxidative stress

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Area of Science:

* Osteoimmunology
* Bone Biology
* Alcohol-Induced Bone Diseases

Background:

* Chronic alcohol consumption negatively impacts skeletal health, causing conditions such as osteoporosis, delayed fracture healing, and osteonecrosis of the femoral head.
* Current treatments for alcohol-related bone disorders are limited, highlighting the need for understanding underlying mechanisms.
* Bone remodeling, a balance between bone formation and resorption, is disrupted by factors including immune system dysfunction.

Purpose of the Study:

* To review current literature on alcoholic osteopenia, focusing on abnormal osteoimmunology signals.
* To explore the mechanisms by which alcohol affects bone remodeling and immune interactions.
* To provide a theoretical basis for preventing and treating alcohol-related bone disorders.

Main Methods:

* A comprehensive literature search was conducted on PubMed from January 1980 to February 2020.
* Keywords included 'alcohol', 'alcoholic osteoporosis', 'alcoholic osteopenia', 'immune', 'osteoimmunology', 'bone remodeling', 'osteoporosis treatment', and 'osteoporosis therapy'.
* Included studies were summarized to evaluate the current understanding and future prospects of alcoholic osteopenia.

Main Results:

* A total of 135 relevant papers were included in the review.
* Approximately 60 papers detailed the mechanisms of alcohol's involvement in bone remodeling.
* Several studies focused on the pathogenesis of alcohol-induced bone damage via osteoimmune pathways.

Conclusions:

* A complex interplay exists between alcohol consumption and bone remodeling processes.
* Intercellular communication within osteoimmunology presents a potential mechanism underlying alcoholic bone disorders.
* Investigating osteoimmune mechanisms is vital for developing targeted drug therapies for alcoholic bone disease.