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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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Recent Breakthroughs in Various Antimicrobial Resistance Induced Quorum Sensing Biosynthetic Pathway Mediated Targets

Mohit Kumar1, Mridula Saxena2, Anil K Saxena3

  • 1Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research, Affiliated to Uttarakhand Technical University, Kashipur 244713, India.

Combinatorial Chemistry & High Throughput Screening
|April 27, 2020
PubMed
Abstract

Insights

Antimicrobial resistance (AMR) is a growing threat, causing widespread infections and deaths. Targeting microbial quorum sensing (QS) offers a novel strategy to develop new antimicrobial agents and combat AMR.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, with millions of deaths annually.
  • AMR is particularly severe in low- and middle-income countries due to inadequate sanitation and healthcare infrastructure.
  • Existing National Action Plans, while crucial, may have limited impact without robust healthcare systems.

Purpose of the Study:

  • To explore microbial quorum sensing (QS) as a key driver of AMR.
  • To identify QS-mediated pathways and targets involved in antimicrobial resistance.
  • To review potential QS inhibitors for developing novel antimicrobial strategies.

Main Methods:

  • Literature review of QS mechanisms in microbial communities.
  • Analysis of QS-mediated virulence and inter-communication pathways.
  • Identification of QS biosynthetic targets and corresponding inhibitors.

Main Results:

  • Microbial QS strengthens microbial communities, contributing to virulence and resistance.
  • Several QS-mediated enzymes and pathways are directly linked to AMR.
  • Specific QS biosynthetic target inhibitors have been identified.

Conclusions:

  • Targeting microbial QS presents a promising approach to mitigate AMR.
  • Identified QS inhibitors can be developed into next-generation antimicrobial agents.
  • Combating AMR requires a multi-faceted approach including novel therapeutic strategies.
Keywords:
Antimicrobial resistance (AMR)anti-QS inhibitorsbiosynthesisdesign of next-generationquorum sensing (QS)target enzymes

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