Natural polysaccharide-based nanodrug delivery systems for targeted treatment of rheumatoid arthritis: A review

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation of the joints, leading to pain, disability, and systemic complications. Conventional treatments often exhibit limitations, including adverse effects and suboptimal bioavailability. To address these challenges, natural polysaccharides-mediated nano drug delivery is a promising vehicle for RA management. This review explores the potential of natural polysaccharides in RA, including chitosan, cellulose, albumin, hyaluronic acid, polylactic acid, alginate, etc. Their biodegradable and biocompatible nature renders them ideal nanomaterials for RA applications. These properties facilitate targeted delivery, improved cellular uptake, and sustained release of therapeutic agents, enhancing their pharmacological effects while minimizing systemic toxicity. Recent advances in nanotechnology have enabled the formulations of polysaccharides that can encapsulate a range of therapeutic agents, including conventional anti-inflammatory drugs and novel biologics. The review also highlights various formulation strategies to optimize the physicochemical properties of polysaccharide-based nano drug delivery systems, including surface modification and combinatorial therapies. Overall, natural polysaccharides represent a versatile and effective approach for developing innovative nano drug delivery systems, offering a promising strategy for the effective treatment of rheumatoid arthritis.