Animal Models for the Evaluation of Theranostic Radiopharmaceuticals

Theranostic is a new field of medicine that combines diagnosis and patient- specific targeted treatment. In the theranostic approach, it is aimed to detect diseased cells by using targeted molecules using disease-specific biological pathways and then destroy them by cellular irradiation without damaging other tissues. Diagnostic tests guide the use of specific therapeutic agents by demonstrating the presence of the receptor/molecule on the target tissue. As the therapeutic agent is administered to patients who have a positive diagnostic test, the efficacy of treatment in these patients is largely guaranteed. As therapeutic efficacy can be predicted by therapeutic agents, it is also possible to monitor the response to treatment. Many diagnostic and therapeutic procedures in nuclear medicine are classified as theranostic. ¹³¹I treatment and scintigraphy are the best examples of the theranostic application. Likewise, ¹⁷⁷Lu / ⁹⁰Y octreotate for neuroendocrine tumors, ¹⁷⁷Lu PSMA for metastatic or treatment-resistant prostate cancer, ⁹⁰Y SIRT for metastatic liver cancer, and ²²³Ra for bone metastasis of prostate cancer are widely used. Moreover, nanoparticles are one of the most rapidly developing subjects of theranostics. Diagnostic and therapeutic agents that show fluorescent, ultrasonic, magnetic, radioactive, contrast, pharmacological drug or antibody properties are loaded into the nanoparticle to provide theranostic use.

This article reviewed general aspects of preclinical models for theranostic research, and presented examples from the literature.

To achieve successful results in rapidly accelerating personalized treatment research of today, the first step is to conduct appropriate preclinical studies.