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Updated: Dec 23, 2025
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung
Aravind Krishnan1, Joshua Hsu1, Jinny S Ha1
1Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, USA.
Purpose:
We aimed to assess the prognostic value of Neutrophil to Lymphocyte Ratio (NLR) on long-term outcomes and graft dysfunction after lung transplantation.
Methods:
We retrospectively reviewed all patients receiving a lung transplant at our institution from 2011 to 2014. The primary exposure was elevated NLR at the time of transplant, defined by NLR>4. The primary outcomes were graft failure and three-year all-cause mortality. Multivariate logistic regression and Kaplan-Meier survival analysis were used to analyze outcomes.
Results:
95 patients were included. 40 patients (42%) had an elevated NLR. Elevated NLR was associated with graft failure (OR: 4.7 [1.2-18.8], p = 0.02), and three-year mortality (OR: 5.4 [1.3-23.2], p = 0.03) on multivariate logistic regression. Patients with elevated NLR demonstrated significantly lower survival on Kaplan-Meier analysis (50% versus 74%, p = 0.02). The c-statistic for our multivariate model was 0.91.
Conclusion:
Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation.
