Crosstalk between apoptosis and autophagy signaling pathways
W Douglas Fairlie1, Sharon Tran2, Erinna F Lee1
1Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
International Review of Cell and Molecular Biology
|April 27, 2020
Summary
Cellular fate involves complex signaling pathways, including apoptosis and autophagy. This review details the molecular crosstalk between these pathways, crucial for cell survival and death.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Cellular fate is regulated by diverse signaling pathways responding to various stimuli.
- Apoptosis, a key cell death mechanism, is executed via intrinsic and extrinsic pathways.
- Autophagy primarily functions in cell survival but can induce cell death.
- Significant molecular crosstalk exists between apoptosis and autophagy due to their critical roles.
Purpose of the Study:
- To review the intricate molecular crosstalk between apoptosis and autophagy.
- To elucidate the diverse mechanisms governing the interplay of these pathways.
- To provide a detailed understanding of how these pathways influence cellular fate.
Main Methods:
- Literature review of molecular mechanisms.
- Analysis of protein-protein interactions.
- Examination of post-translational modifications.
- Investigation of molecular component degradation pathways.
Main Results:
- Identified diverse crosstalk mechanisms between apoptosis and autophagy.
- Detailed protein-protein interactions and post-translational modifications.
- Highlighted the role of molecular component degradation in pathway crosstalk.
- Demonstrated the complex interconnections influencing cell fate decisions.
Conclusions:
- The crosstalk between apoptosis and autophagy is multifaceted and essential for cellular regulation.
- Understanding these interconnections is vital for comprehending cell survival and death.
- This review consolidates current knowledge on these critical cellular processes.
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