Molecular subtyping bladder cancer: Is it ready for clinical practice?

Area of Science:

• Oncology
• Cancer Biology

Background:

• Bladder cancer is a common and heterogeneous malignancy.
• Current classification (histology, staging) has limitations in predicting treatment response.
• Patient heterogeneity necessitates improved stratification for effective therapy.

Purpose of the Study:

• To address the need for better patient stratification in bladder cancer.
• To explore molecular classifications for improved therapeutic outcomes.

Main Methods:

• Review of proposed molecular classifications for muscle-invasive bladder cancer.

Main Results:

• Molecular classifications for muscle-invasive bladder cancer have been proposed.
• Clinical utility of current molecular classifications is limited.
• Complexity of methods and subtype diversity hinder clinical application.

Conclusions:

• Improved molecular classification is crucial for personalized bladder cancer treatment.
• Overcoming limitations in current molecular approaches is essential for clinical practice.