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High-Resolution Esophageal Manometry in Myasthenia Gravis
Gustavo Torres-Barrera1, Gilberto Herrera-Quiñones1, Susana Isabel Scharrer1
1Department of Gastroenterology and Endoscopy, University Hospital "Dr. José E. González", Monterrey, Nuevo Leon, Mexico.
ACG Case Reports Journal
|April 28, 2020
Summary
Myasthenia gravis, an autoimmune disorder, causes muscle weakness due to antibodies attacking acetylcholine receptors. Early diagnosis is key, especially when dysphagia is a primary symptom.
Area of Science:
- Neurology
- Immunology
- Gastroenterology
Background:
- Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder.
- Antibodies targeting acetylcholine receptors cause progressive muscle weakness.
- Dysphagia can be a significant presenting symptom in MG.
Observation:
- A patient presented with unexplained dysphagia, dysphonia, and dysarthria, symptoms not immediately indicative of MG.
- Diagnostic evaluation included high-resolution esophageal motility studies and edrophonium infusion.
Findings:
- Esophageal motility findings, alongside the response to edrophonium, suggested a diagnosis of myasthenia gravis.
- The study highlights dysphagia as a potentially presenting or dominant symptom in MG.
Implications:
- Recognizing dysphagia as a key symptom can facilitate earlier diagnosis of myasthenia gravis.
- Esophageal motility assessment is a valuable tool in diagnosing MG, especially when bulbar symptoms are prominent.
- Prompt diagnosis and management of MG are crucial for improving patient outcomes in this treatable condition.
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