Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters
Anthony D Garcia1, Matthew C Leech1, Alessia Petti1
1School of Science, University of Greenwich, Chatham, Kent, Chatham Maritime ME4 4TB, United Kingdom.
Abstract:
A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.
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