RIFM fragrance ingredient safety assessment, cinnamyl alcohol, CAS Registry Number 104-54-1

Area of Science:

• Toxicology
• Environmental Safety
• Chemical Safety Assessment

Background:

• Cinnamyl alcohol is widely used in various applications.
• Comprehensive safety data is essential for regulatory compliance and consumer protection.

Purpose of the Study:

• To evaluate the safety of cinnamyl alcohol across multiple toxicological and environmental endpoints.
• To determine the risk profile for human health and the environment.

Main Methods:

• Genotoxicity assays, repeated dose toxicity, developmental and reproductive toxicity assessments.
• Local respiratory toxicity, phototoxicity, and skin sensitization evaluations.
• Environmental fate and effects analysis, including PBT assessment and risk quotient calculation.

Main Results:

• Cinnamyl alcohol demonstrated no genotoxicity.
• Margins of exposure (MOE) >100 for repeated dose and respiratory toxicity via read-across to cinnamaldehyde.
• Exposure below threshold of toxicological concern (TTC) for developmental/reproductive toxicity.
• No Expected Sensitization Induction Level (NESIL) established for skin sensitization.
• Not expected to be phototoxic/photoallergenic.
• Found not to be persistent, bioaccumulative, and toxic (PBT) with risk quotients <1.

Conclusions:

• The safety assessment supports the current use of cinnamyl alcohol.
• Cinnamyl alcohol presents a low risk to human health and the environment based on the evaluated endpoints.