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Related Concept Videos

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Association Between BMP2 Functional Polymorphisms and Sheep Tail Type.

Zengkui Lu1,2, Jianbin Liu1,2, Jilong Han1,2

  • 1Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.

Animals : an Open Access Journal From MDPI
|April 29, 2020
PubMed
Summary
This summary is machine-generated.

Bone morphogenetic protein 2 (BMP2) influences sheep tail fat. Genetic variations in BMP2 correlate with tail length and affect fat deposition genes, suggesting BMP2

Keywords:
BMP2SNPspreadipocytessheeptail type

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Area of Science:

  • Animal Genetics
  • Molecular Biology
  • Livestock Science

Background:

  • Bone morphogenetic protein 2 (BMP2) is a key gene selected in sheep breeds with varying tail types.
  • The precise role of BMP2 in sheep tail fat deposition is not fully understood.

Purpose of the Study:

  • Investigate genetic variations and haplotype combinations of the BMP2 gene in sheep with different tail types.
  • Elucidate the molecular mechanisms underlying BMP2's role in sheep tail fat deposition.

Main Methods:

  • Analyzed three single nucleotide polymorphisms (SNPs) in the BMP2 gene in 533 sheep.
  • Assessed allele and genotype frequencies, Hardy-Weinberg equilibrium, and linkage disequilibrium.
  • Examined the expression of PPARγ and LPL genes following BMP2 overexpression in vitro.

Main Results:

  • Identified three SNPs (g.48401619 T > A, g.48401272 C > A, g.48401136 C > T) significantly correlated with sheep tail length.
  • Observed linkage disequilibrium between g.48401272 C > A and g.48401136 C > T, with CACT as the predominant genotype.
  • BMP2 overexpression upregulated PPARγ and LPL gene expression, indicating involvement in fat metabolism.

Conclusions:

  • The BMP2 gene plays a role in sheep tail fat deposition.
  • BMP2 variations can be utilized for molecular-marker-assisted selection of sheep tail types.