Molecular Biology Approaches to Understanding Spondyloarthritis
Adam Berlinberg1, Kristine A Kuhn1
1Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court Mail Stop B115, Aurora, CO 80045, USA.
Abstract:
New and emerging molecular techniques are expanding understanding of the pathophysiology of spondyloarthritis (SpA). Genome-wide association studies identified novel pathways in antigen processing and presentation as well as helper T cell type 17 (TH17) immunity associated with SpA. Immune cell profiling techniques have supported TH17 immune responses and increasingly are revealing intestinal mucosal immune cells as associated with disease. Emerging technologies in epigenetics, transcriptomics, microbiome, and proteomics/metabolomics are adding to these, refining disease pathways and potentially identifying biomarkers for diagnosis and treatment responses. This review describes many of the new molecular techniques that are being utilized to investigate SpA.
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